Description

ZYMOX® PLUS Otic Ear Solution is a powerful, advanced formula designed to help manage chronic and stubborn ear issues in dogs and cats. Built on the trusted LP3 Enzyme System and enhanced with additional biofilm-targeting enzymes, this solution works to break down the protective barriers that allow resistant bacteria and yeast to thrive.

Ideal for pets dealing with recurring ear problems, ZYMOX PLUS provides antibacterial, antifungal, and anti-yeast support—all in a gentle, no-stress application that requires no pre-cleaning. This helps preserve enzyme effectiveness while reducing discomfort for sensitive ears.

Formulated with 1% hydrocortisone, it delivers fast relief from itching, inflammation, and irritation caused by dermatitis or minor ear conditions. Perfect for pets experiencing head shaking, ear odor, or chronic buildup, this solution simplifies ear care with a once-daily application.

Key Benefits

Advanced Biofilm Support – Targets resistant organisms and hard-to-treat ear issues
Triple Action Formula – Antibacterial, antifungal, and anti-yeast properties
1% Hydrocortisone – Helps relieve itching and inflammation quickly
No Pre-Cleaning Needed – Preserves enzyme activity and reduces ear sensitivity
Ideal for Chronic Issues – Great for recurring infections, odor, and buildup
Easy Once-Daily Use – Stress-free application for pets and owners
Safe for Dogs & Cats – Suitable for pets of all ages

Best For

Chronic or recurring ear infections
Yeast-related ear issues
Pets with ear odor, discharge, or debris
Itchy ears, head shaking, or inflammation
Situations where extra biofilm support is needed

Product Details

Size: 1.25 oz
Active Ingredient: 1% Hydrocortisone
Use: Ear care for dogs and cats
Application: Once daily (follow label directions)

Is this the right ear solution for my pet?

Choose Zymox PLUS Otic if your pet has:

Recurring ear issues that return after routine care
Persistent ear odor, discharge, or head shaking
Itchy, irritated ears that need fast soothing
Situations where you want stronger help than standard enzymatic ear drops

How it works

Zymox’s LP3 Enzyme System supports the ear’s natural defenses by breaking down microbial structures associated with common ear problems in pets. PLUS Otic adds additional enzymes aimed at disrupting biofilm, helping the solution reach and work on hard-to-address ear gunk. The 1% hydrocortisone provides targeted relief for redness and itch.

How to use (once daily)

Do not pre-clean the ear canal.
Fill the ear canal liberally with Zymox PLUS Otic.
Gently massage the base of the ear for 30–60 seconds.
Wipe away any excess. Repeat once daily as directed on the product label.

Tip: Consistency matters. Daily use as directed helps address dog ear infections symptoms like itchy ears and yeast-related debris.

Safety & storage

For external ear use only on dogs and cats.
Do not use if you suspect a ruptured eardrum. If symptoms worsen or fail to improve, consult your veterinarian.
Store at room temperature. Keep out of reach of children and pets.

Common mistakes to avoid

Stopping treatment too early once ears “look better”
Pre-cleaning the ear (can reduce enzyme effectiveness)
Skipping days — daily use helps resolve stubborn issues

Compare Zymox Ear Solutions

Feature	PLUS Otic (this page)	Enzymatic (steroid-free)	Hydrocortisone 1.0%
Enzyme System	LP3 + additional enzymes for biofilm support	LP3 (standard enzymatic)	LP3 (standard enzymatic)
Hydrocortisone	1.0% anti-itch relief	None (steroid-free)	1.0% anti-itch relief
Best For	Recurring/stubborn ear issues; strong odor/debris	Routine ear care, mild cases, maintenance	Itchy, inflamed ears that need soothing
Pre-cleaning Required?	No	No	No
Use Frequency	Once daily per label	Once daily per label	Once daily per label

FAQs

Can Zymox PLUS Otic be used for ear yeast in dogs?: It’s designed to help with common ear issues associated with yeast and bacteria. For severe or persistent cases, consult your vet.
Is it safe for cats?: Yes — for dogs and cats when used as directed.
Do I need to clean the ear first?: No. Pre-cleaning can disrupt the enzymes. Wipe away excess after application.
When should I see a vet?: If there’s no improvement, if symptoms worsen, or if you suspect a ruptured eardrum.

Why Choose Zymox PLUS Otic?

Advanced enzyme + biofilm-reducing system designed for **resistant infections**
Contains **1% hydrocortisone** for itch & inflammation relief
No pre-cleaning necessary — gentle and fear-free application
Once-daily dosing — simple, consistent routine
Safe for dogs & cats (any age, unless contraindicated)

How It Works

Zymox PLUS Otic combines the patented LP3 Enzyme System with **four additional biofilm-reducing enzymes**.
This advanced formula penetrates and disrupts biofilms (the protective layers bacteria form) to allow enzyme action against bacteria, fungi, and yeast.
Meanwhile, 1% hydrocortisone helps reduce itching, swelling, and discomfort in the ear canal.

When to Use Zymox PLUS Otic

This variant is ideal when you suspect a tougher, persistent or chronic ear infection — especially those involving biofilm-forming bacteria or recurring cases that are harder to treat with standard formulas.

How to Use

Do not clean the ear prior to use (pre-cleaning disrupts the enzyme system)
Fill the canal liberally with the solution
Gently massage at the base of the ear for 30–60 seconds to distribute
Wipe away excess fluid
Apply once daily for the recommended treatment period

Frequently Asked Questions

Can I use it with a ruptured eardrum?: No — do not use if eardrum is ruptured or suspected to be ruptured.
Do I need to clean the ear first?: No — this product is formulated to work without pre-cleaning, to preserve enzyme activity.
When should I stop use?: If the condition worsens or does not improve in a few days, discontinue and consult a veterinarian.
Is it safe for kittens or puppies?: Yes — safe for both dogs and cats of all ages unless otherwise contraindicated (e.g. known corticosteroid sensitivity).

How Zymox PLUS Otic Compares to Other Zymox Options

Feature / Use Case	Zymox PLUS Otic	Zymox Enzymatic	Zymox Hydrocortisone (1.0%)
Enzyme + Biofilm Support	Enhanced (LP3 + 4 extra biofilm enzymes)	Standard LP3 enzyme system	Standard LP3 enzyme system
Hydrocortisone / Anti-itch	1.0% hydrocortisone	None	1.0% hydrocortisone
Best Use Case	Persistent / resistant ear infections, recurring otitis	Routine / preventive ear care, mild irritation	Itching / inflammation cases needing corticosteroid support
Pre-cleaning Needed?	No	No	No
Application Frequency	Once daily	Once daily	Once daily

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Always follow veterinarian advice. This product is not a substitute for professional veterinary diagnosis or treatment.

Uses

Resistant otitis
Antibacterial, antifungal, anti-yeast
Antibiofilm technology
Itch relief
Irritated or inflamed ears
Removal of ear exudate
Promotes healthy ears
For dogs and cats
For pets who swim
Pets who live in moist or hot environments

Features

Soothing
Non-toxic
No PRE-CLEANING of the ear
Fear-free ear care
Easy, once daily application
No antibiotics

Made in the USA.

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ZYMOX PLUS Otic 1% Hydrocortisone 1.25 oz